Patient concern | More likely to accept | Less likely to accept |
---|---|---|
Comfort and safety | • Accessible biopsy site • Good post-biopsy care offered • Collection of research tissue during standard procedures | • Challenging biopsy site • Post-biopsy care not explained • Additional visits or procedures for tissue collection |
Risks and benefits | • Given sufficient information about purpose of the research and need for biopsies • Risks of tumour seeding explained • Other risks, including discomfort at biopsy site, fully explained • Lack of direct benefit fully explained • Research is considered ‘exciting’ – involving and educating patients • Research will improve outcomes in future patients and exclude unnecessary treatment in future patients | • Not given sufficient information about purpose, risks and benefits |
Timing | • Given adequate time to decide | • Badly timed or insensitive introduction to trial |
Quality control | • Clear explanation of what happens to the samples | • Use of samples not adequately explained |
History | • Patients with metastatic disease • Family history | • Previous poor experiences of research |